重组人胸腺肽a1

长链重组人胰岛素样生长因子1(L -R3-IGF-1)冻干

[编辑:吉林省敖腾生物] [时间:2014-05-27]


 

产品名称:长链重组人胰岛素样生长因子1(L -R3-IGF-1)冻干粉原料

吉林敖腾生物科技有限责任公司成立于2011年,是集重组蛋白类多肽、蛋白质及酶的研发、生产及销售一体化的高新技术企业。公司的生产基地位于吉林省敦化经济技术开发区,拥有现代化的办公大楼及研发生产大楼。生产车间面积4500平方米。能够大批量生产重组牛肠激酶(rEK)、重组人表皮生长因子(rhEGF)、重组人胰岛素样生长因子1(LR3-IGF-1)、重组人干扰素α2b、胸腺肽a1等产品,供广大科研机构及企业使用。

 

General Information
Human Long Arg3 Insulin-like Growth Factor-I (Long-R3-IGF-I) is an 83 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus. Scientists have engineered this analog with the express purpose of increasing biological activity. Human Long-R3-IGF-I is significantly more potent than human IGF-I in vitro. The enhanced potency is due to the markedly decreased binding of human Long-R3-IGF-I to IGF binding proteins which normally inhibit the biological actions of IGFs.
 
Expression Host: E. coli.
 
Molecular Mass:
The recombinant human Long-R3-IGF-I has a calculated molecular mass of  9111Da.
 
Formulation:
Lyophilized from sterile PBS , pH 7.2, and 5 % mannitol are added as protectants before lyophilization.
 
Quality Control
Purity: as determined by the following methods:
(a)  > 95%, RP-HPLC analysis.
(b) >98%, SDS-PAGE analysis.
Bio-activity:
The ED50 of recombinant human Long R3 IGF-I, calculated by the dose-dependant proliferation of murine BALBC 3T3 cells, is less than 1.0ng/ml, corresponding to a specific activity of 1.0×106 IU/mg.
Endotoxin:
﹤1.0 EU per mg as determined by the LAL method.  
  
Product specification
100μg/vial;500μg/vial;1mg/vial.
 
Store at

2-8oC for two years or -20oC for long term storage. Avoid repeated freeze and thaw.

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